Depression Linked to Cellular Endocrine Clock in Broken Brains

Holy Hormones Journal – The NEI Supersystem – the neurological – endocrine and immune system is crucial to women’s health and well-being.  It is the Holy Grail. Women’s hormonal menstrual and fertility cycles are evidence of this synchrony.  Disrupting the circadian endocrine rhythm is really what is killing us. Our bodies are geared to adapt to changes in our lifestyles – but if that endocrine/hormone clock in broken brains becomes unwound… we slowly and painfully die. Awareness is crucial. All of this life enhancing information is in my new book, ‘Understanding Your Mind, Mood and Hormone Cycle‘.

Read more about the Female Mystique: The Three Phases of Eve  – this is important information for you to understand the cyclical phases you go through every month.  Maiden, Mother and Wise Woman – you are all three – every month of your life.

This is the simple reason why women struggle in a man’s world. The sad thing is – that men are now struggling in the world they made.  When the world evolved around lunar calendars – and people started each month with the new moon – and waxed and waned with the lunar cycle – they were all living naturally with the circadian rhythms of their bodies and their environment.

Out of Sync: Body Clocks Altered at Cell Level in Depression

May 13, 2013

circadian and depressionMay 13, 2013 — Every cell in our bodies runs on a 24-hour clock, tuned to the night-day, light-dark cycles that have ruled us since the dawn of humanity. The brain acts as timekeeper, keeping the cellular clock in sync with the outside world so that it can govern our appetites, sleep, moods and much more.

But new research shows that the clock may be broken in the brains of people with depression — even at the level of the gene activity inside their brain cells.

It’s the first direct evidence of altered circadian rhythms in the brain of people with depression, and shows that they operate out of sync with the usual ingrained daily cycle. The findings, in the Proceedings of the National Academy of Sciences, come from scientists from the University of Michigan Medical School and other institutions.

The discovery was made by sifting through massive amounts of data gleaned from donated brains of depressed and non-depressed people. With further research, the findings could lead to more precise diagnosis and treatment for a condition that affects more than 350 million people worldwide.

What’s more, the research also reveals a previously unknown daily rhythm to the activity of many genes across many areas of the brain — expanding the sense of how crucial our master clock is.

In a normal brain, the pattern of gene activity at a given time of the day is so distinctive that the authors could use it to accurately estimate the hour of death of the brain donor, suggesting that studying this “stopped clock” could conceivably be useful in forensics. By contrast, in severely depressed patients, the circadian clock was so disrupted that a patient’s “day” pattern of gene activity could look like a “night” pattern — and vice versa.

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Author: Leslie Carol Botha

Author, publisher, radio talk show host and internationally recognized expert on women's hormone cycles. Social/political activist on Gardasil the HPV vaccine for adolescent girls. Co-author of "Understanding Your Mood, Mind and Hormone Cycle." Honorary advisory board member for the Foundation for the Study of Cycles and member of the Society for Menstrual Cycle Research.