Who’s Your Mommy? Mice Stem Cells Produce – Baby Mice

Leslie Carol Botha: Scientists are hoping to bypass legal and ethical issues to use this emerging stem cell science as a new tool for treating infertility.

There was a recent report of the first mother-daughter uteri transplants in Sweden.  One woman was born without a womb – the other lost her uterus after getting cervical cancer.  The outcome for this radical transplant will be using IVF to impregnate the two women.  Now, mice egg and sperm cells are being created in a petri dish. Beware women – not only have we been lead to believe we do not have to menstruate – we will soon not be able to pro-create.  We will lose final control over our bodies.  All we will be needed for is surrogacy to carry the implanted embryo into our wombs.

Special thanks to Michael Cook with BioEdge for reporting on this. Michael poses the question “is this what a slippery slope is?”

According to Cook:

The researchers tinkered with a few genes in the cells, turning them into cells very much like primordial germ cells. They then cultured the cells with female mouse gonadal cells, creating a “reconstituted ovary,” which was then transplanted to a mouse ovary or kidney.

Transplanted uteri,  ‘reconstituted ovaries’ and stem cell embryos.  The answer to Cook’s question is yes.  And if we do not realize it soon enough women will be sliding down that slope as fast as a skier at the Olympics.

Sperm and Eggs Created in Dish Produce Mouse Pups

Science Now
by Dennis Normile on
4 October 2012, 2:10 PM

Credit: Mitinori Saitou and Katsuhiko Hayashi


Want baby mice? Grab a petri dish. After producing normal mouse pups last year using sperm derived from stem cells, a Kyoto University team of researchers has now accomplished the same feat using eggs created the same way. The study may eventually lead to new ways of helping infertile couples conceive.

“This is a significant achievement that I believe will have a sustained and long-lasting impact on the field of reproductive cell biology and genetics,” says Amander Clark, a stem cell biologist at University of California, Los Angeles.

The stem cells in both cases are embryonic stem (ES) cells and induced pluripotent stem (iPS) cells. The former are taken from embryos and the latter are adult tissue cells that are reprogrammed to act like stem cells. In theory, both can produce all of the body’s cell types, yet most researchers have been unable to turn them into germ cells, precursors of sperm and eggs.

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Author: Leslie Carol Botha

Author, publisher, radio talk show host and internationally recognized expert on women's hormone cycles. Social/political activist on Gardasil the HPV vaccine for adolescent girls. Co-author of "Understanding Your Mood, Mind and Hormone Cycle." Honorary advisory board member for the Foundation for the Study of Cycles and member of the Society for Menstrual Cycle Research.