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Why progesterone causes mood changes
Jan. 26th, 2010 at 8:02 AM
The brain has both estrogen and progesterone receptors. In women who have epilepsy, seizures are known to occur more frequently during times of high estrogen (late follicular phase and ovulation) and they are decreased when progesterone is high. In this sense, progesterone acts a a brain anesthetic to some degree. High doses of progesterone can be very sedating.

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