New York, NY
June 21, 2009
The purpose was to study the perinatal transmission of human papillomavirus DNA (HPV-DNA) in 63 mother-newborn pairs, besides looking at the epidemiological factors involved in the viral DNA transmission. The following sampling methods were used: (1) in the pregnant woman, when was recruited, in cervix and clinical lesions of the vagina, vulva and perineal region; (2) in the newborn, (a) buccal, axillary and inguinal regions; (b) nasopharyngeal aspirate, and (c) cord blood; (3) in the children, buccal was repeated in the 4th week and 6th and 12th month of life.
HPV-DNA was identified using two methodologies: multiplex PCR (PGMY09 and MY11 primers) and nested-PCR (genotypes 6/11, 16, 18, 31, 33, 42, 52 and 58). Perinatal transmission was considered when concordance was found in type-specific HPV between mother/newborn or mother/child.
HPV-DNA genital was detected in 49 pregnant women submitted to delivery. Eleven newborns (22.4%, n=11/49) were HPV-DNA positive.
In 8 cases (16.3%, n=8/49) there was type specific HPV concordance between mother/newborn samples. At the end of the first month of life three children (6.1%, n=3/49) became HPV-DNA positive, while two remained positive from birth.
In 3 cases (100%, n=3/3) there was type specific HPV concordance between mother/newborn samples. In the 6th month, a child (2%, n=1/49) had become HPV-DNA positive between the 1st and 6th month of life, and there was type specific HPV concordance of mother/newborn samples.
All the HPV-DNA positive children (22.4%, n=11/49) at birth and at the end first month of life (6.1%, n=3/49) became HPV-DNA negative at the age of 6 months. The HPV-DNA positive child (2%, n=1/49) from 1st to the 6th month of life became HPV-DNA negative between the 6th and 12th month of life and one child had anogenital warts.
In the twelfth month all (100%, n=49/49) the children studied were HPV-DNA negative. A positive and significant correlation was observed between perinatal transmission of HPV-DNA and the immunodepression of maternal variables (HIV, p=0.007).
Finally, the study suggests that perinatal transmission of HPV-DNA occurred in 24.5% (n=12/49) of the cases studied.
Author: Renato RombaldiEduardo SerafiniJovana MandelliEdineia ZimmermannKamille Losquiavo
Credits/Source: Virology Journal 2009, 6:83
Comment from Leslie
Disturbing news at best.. The HPV Vaccine is useless against HPV positive girls – HPV testing is not being done – AND FDA documents state that if a girl with HPV is vaccinated her chances of getting cervical cancer increase astronomically. Check the papers under Global Concerns About Gardasil for details.
HPV is not any different than HIV transmission.