Holy Hormones Journal: Here’s the rub: the brain may be “the next ‘battleground’ for extending the lives of women with breast cancer,” but the fight does not have to be a new ‘war’. If the brain is nutrated with the amino acids and minerals – along with vitamins, it will be able to fend off those disguised cells. Most of us have tumors in our body that come and go… throughout our lives. It is when we get older and our neuro-endocrine-immune system becomes weaker, then the problems begin. The body no longer has the tools it needs to defend itself from the ‘enemy’. If the neurotransmitters are healthy and communicating then the enemy will retreat.
Isn’t anyone else tired of women’s bodies considered as battlefields crawling with disguised marauders?
Think it is time to change up the language – get the male speak out and realize that there is a more peaceful, non-invasive, non-drug approach to women’s health. Prevention, nutrition, and living with cycles. Everything else puts money of the pockets of the profiteers as they continue to fight the ‘war on women’ in our bodies, our heads, in our homes and at work.
Breast Cancer Cells Disguise Themselves as Neurons to Cause Brain Tumors
January 14, 2014
Treatment and “cure” of breast cancer doesn’t ensure that the disease won’t spread to the brain. Too often, sometimes years after an initial diagnosis and remission, breast cancer cells are discovered growing as new tumors within the brain. Now City of Hope researchers have found how this happens.
Breast cancer cells masquerade as neurons, allowing them to hide from the immune system, cross the blood-brain barrier and begin to form ultimately-deadly brain tumors, the researchers found.
“The most dreaded location for cancer to spread is the brain,” said Rahul Jandial, a City of Hope neurosurgeon who led the study, available online and slated for print publication in the Proceedings of the National Academy of Sciences in February. “As we have become better at keeping cancer at bay with drugs such as Herceptin, women are fortunately living longer. In this hard-fought life extension, brain metastastes are being unmasked as the next battleground for extending the lives of women with breast cancer.”
Jandial and other City of Hope scientists wanted to explore how breast cancer cells cross the blood-brain barrier — a separation of the blood circulating in the body from fluid in the brain — without being destroyed by the immune system.
“If, by chance, a malignant breast cancer cell swimming in the bloodstream crossed into the brain, how would it survive in a completely new, foreign habitat?”Jandial said. Jandial and his team’s hypothesis: Given that the brain is rich in many brain-specific types of chemicals and proteins, perhaps breast cancer cells exploit these resources by assuming similar properties. These cancer cells could potentially deceive the immune system by blending in with the neurons, neurotransmitters, other types of proteins, cells and chemicals.
Taking samples from brain tumors resulting from breast cancer, Jandial and his team found that the breast cancer cells were using the brain’s most abundant chemical as a fuel source. This chemical, GABA, is a neurotransmitter used for communication between neurons.
When compared to cells from non-metastatic breast cancer, the metastasized cells expressed a receptor for GABA, as well as for a protein that draws the transmitter into cells. This allowed the cancer cells to essentially masquerade as neurons.