25, 179–184, August 2006 ª2006 Elsevier Inc. DOI 10.1016/j.immuni.2006.08.002
1Centre for Immunology and Cancer Research
The University of Queensland
4th Floor Research Extension
Princess Alexandra Hospital
Woolloongabba Q’land 4102
An Australian newspaper recently bestowed Ian Frazer
the title of ‘‘God’s gift to women’’ for his research
team’s part in developing a vaccine to help control
cervical cancer. Here Frazer discusses this work and
the science behind the vaccine.
Designed to prevent infection with some types of human
papillomavirus (HPV), a vaccine (Gardasil) recently approved
by the Food and Drug Administration for use in
9- to 26-year-old women in the USA is the first pharmaceutical
compound specifically developed to prevent
the common human malignancy cervical cancer. Another
similar product (Cervarix) should become available
next year. These are conventional protein-adjuvant
vaccines, comprising alum adjuvanted viral capsids of
multiple HPV serotypes assembled from recombinant
viral capsid protein. The vaccines, delivered systemically,
induce neutralizing antibody, protecting against
infection with the incorporated HPV serotypes in skin
and at mucosal surfaces.
HPV – God’s gift to women….another case of men getting involved with the natural cycles of women’s health crying triumvirate….Off with his balls, I say.
It is time for women to take control of their own health…..it is time to remember the source of our being instead of letting some egomaniac dictate what is good for us.