HPV Vaccine enhanced with an adjuvant

Vaccine Injury Help Center

Posted on June 6, 2011 by Vaccine Injury Lawyer

According to an article for Medical News Today, “The immune response against the virus that causes cervical cancer is stronger and sustained following vaccination with GlaxoSmithKline’s (GSK) candidate HPV vaccine formulated with the innovative AS04 adjuvant compared to using the same vaccine formulated with a conventional aluminium salt adjuvant.”

Adjuvants are substances, which when used in combination with antigens in vaccines, enhance the immune response. The use of adjuvants in vaccines is very common. Vaccines have conventionally been formulated with aluminium salt as the adjuvant.

So, what does this really mean? In layman’s terms, it means that this particular HPV vaccine has been enhanced, made stronger, by adding a special AS04 adjuvant to it compared to the aluminum salt additive.

Dr. Philippe Monteyne, Head of Global Vaccine Development of GSK Biologicals, said: “For a HPV vaccine to be effective, it must induce a strong immune response and provide protection that lasts. These new data demonstrate a genuine immunological benefit with the AS04 adjuvant by contributing to a strong and sustained vaccine-induced immune response of high quality.”

In these studies, GSK’s HPV vaccine, formulated with the innovative AS04 adjuvant, and the same vaccine formulated with a conventional aluminium salt adjuvant were compared to assess the quality of the immune response generated after vaccination.

In human studies, subjects received a three-dose course (at 0, 1 and 6 months) of GSK’s HPV vaccine formulated with either the innovative AS04 adjuvant or a conventional aluminium salt adjuvant. Following vaccination, antibody levels and immune memory B-cells were measured.

Results in human subjects showed that enhanced antibody levels induced by the AS04 adjuvanted HPV vaccine were 1.5 and 2.1 times higher for HPV 16 and HPV 18 respectively, at 3.5 years post-vaccination, compared to those induced following vaccination with the same vaccine formulated with a conventional aluminium salt adjuvant.

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Author: Leslie Carol Botha

Author, publisher, radio talk show host and internationally recognized expert on women's hormone cycles. Social/political activist on Gardasil the HPV vaccine for adolescent girls. Co-author of "Understanding Your Mood, Mind and Hormone Cycle." Honorary advisory board member for the Foundation for the Study of Cycles and member of the Society for Menstrual Cycle Research.