Quantifying the possible cross-reactivity risk of an HPV16 vaccine

SANE Vax Inc.

Darja Kanduc, Department of Biochemistry and Molecular Biology, University of Bari, Italy

Correspondence to: D. Kanduc, Department Biochemistry and Molecular Biology, University of Bari, Bari 70126 – Italy.

Telephone: 39 080 544 3321; Fax: 39 080 544 3321. Email: d.kanduc@biologia.uniba.it; dkanduc@gmail.com

(Received: March 18, 2009; accepted: May 5, 2009)

Background: The potential adverse events associated with vaccination for infectious diseases underscore the need for effective analysis and definition of possible  vaccine side effects. Using the HPV16 proteome as a model, we quantified the actual and theoretical risks of anti-HPV16 vaccination, and defined the potential disease spectrum derived from concomitant cross-reactions with the human organism.

Methods: We searched the primary sequence of the HPV16 proteome for heptamer aminoacid sequences shared with human proteins using the Protein International  Resource database.

Results: The human proteome contains 82 heptapeptides and two octapeptides found in HPV16. The viral matches are spread among proteins involved in fundamental processes, such as cell differentiation and growth and neurosensory regulation. The human proteins containing the HPV16-derived heptamers include celladhesion molecules, leukocyte differentiation antigens, enzymes, proteins associated with spermatogenesis, transcription factors, and neuronal antigens. The number of viral matches and their locations make the occurrence of side autoimmune cross-reactions in the human host following HPV16-based vaccination almost unavoidable.

Conclusions: Any antigen-based vaccine needs to be carefully and thoroughly designed and critically screened for potential side effects by comparing sequence similarity at the molecular level.

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Author: Leslie Carol Botha

Author, publisher, radio talk show host and internationally recognized expert on women's hormone cycles. Social/political activist on Gardasil the HPV vaccine for adolescent girls. Co-author of "Understanding Your Mood, Mind and Hormone Cycle." Honorary advisory board member for the Foundation for the Study of Cycles and member of the Society for Menstrual Cycle Research.