A condition in which bones become thin and porous as a result of calcium loss, osteoporosis affects women eight times more than men. A bone scan can determine if one has this condition. Statistics say that one in two women over age fifty, or a woman in menopause, will suffer at least one lifetime fracture from osteoporosis. There is recent evidence that biomimetic rhythmic bioidentical hormone therapy can prevent osteoporosis.
Research studies have also shown that hormone replacement therapy (HRT) lowers the risk of osteoporosis-related hip fractures and other fractures in postmenopausal women. When we run out of estrogen and progesterone hormones, our bones begin to die very quickly. Bones have their own life cycle or metabolism, a rhythm of growth and death governed by estrogen and progesterone. The fall off of estrogen during perimenopause means no peak of estrogen activity to make progesterone receptors which would build bone. This is the beginning of osteoporosis.
Estrogen controls osteoclast activity. Osteoclasts are bone cells that “eat up” old bone for disposal. Progesterone controls osteoblastic activity. Osteoblasts are bone cells that build fresh new bone. In this case progesterone grows bone, and estrogen takes it away so that new bone can grow again next month. Without this balanced interplay, one of two things can happen: Without estrogen, bone would overgrow into a cancer- like state, or without progesterone, unopposed estrogen would make bones thin, fragile, and porous – osteoporotic.
Women in menopause who take rhythmic hormones are seeing reversal of bone loss, and the end of osteoporosis. Why? Because it is rhythmic biomimetic bioidentical hormone replacement that helps slow bone thinning or loss and causes an increase in bone thickness. Estrogen replacement alone, because it takes away bone, should be bad for osteoporosis and seems to be so in conventional low doses. But estrogen replacement helps for a little while because it does prevent apoptosis in the bone-building cells, the osteoblasts; however, unless progesterone comes in to stimulate osteoblasts, not much bone grows from estrogen replacement alone.