Study: BPA Exposure Alters Genome in Fetal Mice – Higher Risk of Estrogen Related Disease in Adolescence

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Holy Hormones Journal:

Not the article one would want to find on a Sunday afternoon. But then again, one we knew was coming.

  • BPA was initially considered for use as a sex hormone drug.
  • It’s actually acts like the hormone produced in a woman’s ovaries, it’s an estrogen.
  • And it’s essentially like a drug in a birth control pill.

~Frederick Vom Saal, PhD., developmental biologist and professor of biology at University of Missouri-Columbia, Miss

Fetal BPA exposure in mice linked to estrogen-related diseases after adolescence

Science Daily
Date:June 17, 2016
Source:Federation of American Societies for Experimental Biology
Summary:The genome is permanently altered in the uterus of mice that had been exposed to BPA during their fetal development, new research indicates.

Low levels of BPA exposure may be considered safe, but new research published online in The FASEB Journal, suggests otherwise. In the report, researchers from Yale show that the genome is permanently altered in the uterus of mice that had been exposed to BPA during their fetal development. These changes were found to mainly affect genes that are regulated by estrogen and are implicated in the formation of estrogen-related diseases such as infertility, endometriosis, endometrial cancer, osteoporosis, prostate cancer, neurodegenerative disease, obesity and breast cancer.

“Our study demonstrates that fetal exposure to BPA leads to a detrimental change in the adult uterine response to estrogens,” said Hugh S. Taylor, M.D., a senior researcher involved in the work and Chief of Obstetrics and Gynecology at Yale-New Haven Children’s Hospital at the Yale School of Medicine in New Haven, Connecticut. “Our study confirms that BPA is an active compound and can negatively impact fetal development and confirms that steps should be taken to reduce maternal consumption of BPA during gestation.”

To make this discovery, Taylor and colleagues used two groups of pregnant mice. One group was exposed to human ranges of BPA by intraperitoneal infusion and the other group was not. The researchers then analyzed the genetic and epigenetic profile of the uterus in the female offspring before sexual maturation and examined how the uterine genes responded to estrogen in each of these groups. They found that even though changes to the uterus may not be present at birth or in early post-natal life, changes become apparent after sexual maturity. The study demonstrated a direct change in the estrogen responses of almost 1,000 genes after fetal BPA exposure.

“This study reaches into the antecedent fetal exposure axis and reveals a striking, delayed onset of uterine gene expression effects in the offspring,” said Thoru Pederson, Ph.D., Editor-in-Chief of The FASEB Journal. “To the extent that these findings could be envisioned to translate to the human, we have in this study a very important body of information.”


Story Source:

The above post is reprinted from materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. E. M. Jorgensen, M. H. Alderman, H. S. Taylor. Preferential epigenetic programming of estrogen response after in utero xenoestrogen (bisphenol-A) exposure. The FASEB Journal, 2016; DOI: 10.1096/fj.201500089R

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Author: Leslie Carol Botha

Author, publisher, radio talk show host and internationally recognized expert on women's hormone cycles. Social/political activist on Gardasil the HPV vaccine for adolescent girls. Co-author of "Understanding Your Mood, Mind and Hormone Cycle." Honorary advisory board member for the Foundation for the Study of Cycles and member of the Society for Menstrual Cycle Research.