Delayed effects of neonatal exposure to Tween 80 on female reproductive organs in rats.


Food Chem Toxicol. 1993 Mar;31(3):183-90.

Gajdová M, Jakubovsky J, Války J.

Institute of Preventive and Clinical Medicine, Limbová, Bratislava.


Neonatal female rats were injected ip (0.1 ml/rat) with Tween 80 in 1, 5 or 10% aqueous solution on days 4-7 after birth. Treatment with Tween 80 accelerated maturation, prolonged the oestrus cycle, and induced persistent vaginal oestrus. The relative weight of the uterus and ovaries was decreased relative to the untreated controls. Squamous cell metaplasia of the epithelial lining of the uterus and cytological changes in the uterus were indicative of chronic oestrogenic stimulation. Ovaries were without corpora lutea, and had degenerative follicles.

PMID: 8473002 [PubMed – indexed for MEDLINE]

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Tween 80 = Polysorbate 80 = Gardasil = Infertility


Author: Leslie Carol Botha

Author, publisher, radio talk show host and internationally recognized expert on women's hormone cycles. Social/political activist on Gardasil the HPV vaccine for adolescent girls. Co-author of "Understanding Your Mood, Mind and Hormone Cycle." Honorary advisory board member for the Foundation for the Study of Cycles and member of the Society for Menstrual Cycle Research.