New Study Shows the Brain Produces Estrogen

Holy Hormones Journal: Science is turning all of our pre-conceived notions upside down. Up until now we have believed that hormone stimulation begins in the brain – triggering the production of the sex hormones in the ovaries.  But what are the implications of estrogen production in the brain?  Add to the synthetic hormones that suppress hormone production? Add to that all of the estrogen mimickers in our environment? Hormone imbalance is real. And it is the root cause for so many diseases that are now affecting the young and old alike.

With so much estrogen in our bodies – is it any wonder that women are having problems ovulating  (annovulatory cycles and infertility) – or that there is a rise in miscarriage rates – or loss of hair or diabetes – or thyroid conditions? Or that our hormone honeys are going into puberty at an earlier and earlier age – and that women in their 30’s and 40’s are experiencing early menopause?

Houston we have trouble. Big trouble.

The brain also produces the sex hormone oestrogen

The female sex hormone oestrogen can be produced and released from the brain as well as the ovaries, according to a study.

December 24, 2013
by Jo Adetunji, The Conversation

thebrainalsoThe research, recently published in the Journal of Neuroscience, shows that the hypothalamus – a part of the brain involved with regulating the menstrual cycle and reproduction – can actively release the hormone in rhesus monkeys. The findings have implications for humans because the reproductive neuroendocrine system (which makes and releases hormones) of rhesus monkeys is identical to humans.

The researchers discovered that estradiol – one of three major naturally occurring oestrogen hormones and the predominant one involved in female reproduction – can be rapidly produced in the brain. Estradiol influences other functions in the body including our weight and memory.

Although scientists had suspected that the hypothalamus area of the brain played a role in regulating the menstrual cycle and reproduction, Ei Terasawa, professor at Wisconsin-Madison’s School of Medicine and Public Health, said the finding that it could rapidly produce estradiol and help control gonadotrophin releasing hormone (GnRH) – protein hormones that help regulate growth, sexual development and reproductive function – still came as a surprise.

“These findings not only shift the concept of how reproductive function and behaviour is regulated but have real implications for understanding and treating a number of diseases and disorders,” Terasawa said.

Although oestrogen is commonly associated with sex and reproduction, and is used in the contraceptive pill to prevent pregnancy, an imbalance of the hormone could be linked to a number of conditions including Alzheimer’s, stroke and depression.

It could also be interesting for women who have been through the menopause and who are given hormones like oestrogen to prevent problems such as osteoporosis and the effects of the menopause including dizziness and fatigue. Or for girls with issues in puberty.

Read full article…


Related Articles

Estrogen: Not just produced by the ovaries
Read carefully: article discussed new areas to target diseases (hypothalamus related) and to develop more drugs.  It is all the synthetic drugs, and fertilizers that have gotten us into this mess in the first place. LB

“Neuroestradiol in the Hypothalamus Contributes to the Regulation of Gonadotropin Releasing Hormone Release.” Brian P. Kenealy, Amita Kapoor, Kathryn A. Guerriero, Kim L. Keen, James P. Garcia, Joseph R. Kurian, Toni E. Ziegler, and Ei Terasawa. The Journal of Neuroscience, 4 December 2013, 33(49): 19051-19059; DOI: 10.1523/JNEUROSCI.3878-13.2013


Author: Leslie Carol Botha

Author, publisher, radio talk show host and internationally recognized expert on women's hormone cycles. Social/political activist on Gardasil the HPV vaccine for adolescent girls. Co-author of "Understanding Your Mood, Mind and Hormone Cycle." Honorary advisory board member for the Foundation for the Study of Cycles and member of the Society for Menstrual Cycle Research.