Ghostwriting misled thousands about HRT, analysis says

CNN Health

September 8th, 2010

Pharmaceutical giant Wyeth paid hundreds of thousands of dollars to ghostwriters to write misleading information about hormone therapy, promoted benefits and downplayed the negative effects of hormones, according to an analysis published in PLoS Medicine.

The analysis by Dr. Adriane J. Fugh-Berman of Georgetown University Medical Center says that Wyeth, now part of Pfizer, manipulated media messages when it used ghostwriters to insert desired messages into articles published in medical journals.

The documents became public when PLoS Medicine and the New York Times argued that ghostwriting undermines public health and that documents backing this practice should be unsealed. A federal judge agreed. The documents are part of litigation by 14,000 women who claim their use of the hormones led to their development of breast cancer.

Wyeth is accused of paying a company – DesignWrite – hundreds of thousands of dollars to produce multiple articles about the benefits of Prempro, a brand of hormone therapy that became the first FDA approved treatment for hot flashes in 1942.

The analysis of those articles found that they “implied that estrogen could preserve youth and health.” Further, the study says, physicians were prescribing estrogen to millions of women who had no symptoms.

“In 1975, an eight-fold increase in endometrial cancer was linked to estrogen use and estrogen sales decreased,” Fugh-Berman wrote. “Today, despite definitive scientific data to the contrary, many gynecologists still believe that the benefits of HT outweigh the risks in asymptomatic women. This non-evidence based perception may be the result of decades of carefully orchestrated corporate influence on medical literature.”

The articles were crafted to downplay the perceived risks of hormone therapy and to promote unproved uses for hormone therapy, such as preventing dementia, Parkinson’s disease, vision problems and wrinkles, according to Fugh-Berman’s analysis.

Use of HRT fell in 2002 after the Women’s Health Initiative study linked the use of hormones to increased risk for breast cancer, ovarian cancer, strokes and other problems.

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Author: Leslie Carol Botha

Author, publisher, radio talk show host and internationally recognized expert on women's hormone cycles. Social/political activist on Gardasil the HPV vaccine for adolescent girls. Co-author of "Understanding Your Mood, Mind and Hormone Cycle." Honorary advisory board member for the Foundation for the Study of Cycles and member of the Society for Menstrual Cycle Research.