Hormonal status in protracted critically illness and in-hospital mortality

Critical Care 2011, 15:R47doi:10.1186/cc10010

Published: 3 February 2011

Tarek Sharshar , Sylvie Bastuji-Garin , Andrea Polito , Bernard De Jonghe , Robert D Stevens , Virginie Maxime , Pablo Rodriguez , Charles Cerf , Herve Outin , Philippe Touraine , Kathleen Laborde and The Groupe de Reflexion et dEtude des Neuromyopathies En Reanimation

Abstract (provisional)


The aim of this study was to determine the relationship between hormonal status and mortality in patients with protracted critical illness.


Prospective observational study in four medical and surgical ICUs. ICU patients regaining consciousness after 7 day of mechanical ventilation were included. Plasma levels of IgF1, prolactin, thyroid stimulating hormone (TSH), follicular stimulating hormone (FSH), lutenizing hormone (LH), estradiol, progesterone, testosterone, dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulphate (DHEAS) and cortisol were measured on the first day patients were awake and cooperative (day 1). Mean blood glucose from admission to day 1 was calculated.


We studied 102 patients, 65 men and 37 women (29 postmenopausal). 24 (24%) patients died in hospital. IgF1 was higher and cortisol lower in survivors. Mean blood glucose was lower in women who survived; DHEA and DHEAS higher in men who survived.


These results suggest that, according to gender, some endocrine or metabolic markers measured in the post-acute phase of critical illness have a prognosis value.

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Author: Leslie Carol Botha

Author, publisher, radio talk show host and internationally recognized expert on women's hormone cycles. Social/political activist on Gardasil the HPV vaccine for adolescent girls. Co-author of "Understanding Your Mood, Mind and Hormone Cycle." Honorary advisory board member for the Foundation for the Study of Cycles and member of the Society for Menstrual Cycle Research.