Critical Care 2011, 15:R47doi:10.1186/cc10010
|Published:||3 February 2011|
Tarek Sharshar , Sylvie Bastuji-Garin , Andrea Polito , Bernard De Jonghe , Robert D Stevens , Virginie Maxime , Pablo Rodriguez , Charles Cerf , Herve Outin , Philippe Touraine , Kathleen Laborde and The Groupe de Reflexion et dEtude des Neuromyopathies En Reanimation
The aim of this study was to determine the relationship between hormonal status and mortality in patients with protracted critical illness.
Prospective observational study in four medical and surgical ICUs. ICU patients regaining consciousness after 7 day of mechanical ventilation were included. Plasma levels of IgF1, prolactin, thyroid stimulating hormone (TSH), follicular stimulating hormone (FSH), lutenizing hormone (LH), estradiol, progesterone, testosterone, dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulphate (DHEAS) and cortisol were measured on the first day patients were awake and cooperative (day 1). Mean blood glucose from admission to day 1 was calculated.
We studied 102 patients, 65 men and 37 women (29 postmenopausal). 24 (24%) patients died in hospital. IgF1 was higher and cortisol lower in survivors. Mean blood glucose was lower in women who survived; DHEA and DHEAS higher in men who survived.
These results suggest that, according to gender, some endocrine or metabolic markers measured in the post-acute phase of critical illness have a prognosis value.