Bone tissue undergoes constant remodeling as old bone is dissolved (resorbed) by special cells called osteoclasts. Through the action of bone-forming cells called osteoblasts, new bone is formed.
The rate of bone resorption and bone formation are closely linked. When healthy hormone balance exists, if bone resorption accelerates for some reason, the body will compensate by increasing the amount of new bone formed. As a result of these control mechanisms, the total amount of bone remains relatively constant.
After menopause, however, due largely to hormonal change, bone resorption and bone formation become uncoupled.
No longer linked as closely as they were before, the rate of bone resorption increases significantly after menopause, but bone formation fails to keep pace with this rise.