PMDD not in our heads but in cellular response to sex hormones



Holy Hormones Journal:

Well what a way to start the New Year – with news that women have been dying (yes, literally) to hear – that PMS and PMDD are not in their heads – but in their cellular response to their sex hormones – estrogen and progesterone. But is this really good news? Or for some like myself a warning that a severe endocrine breakdown is happening causing this abnormal response/signalling from two of the most fundamental hormones that define our ability to procreate.

For the moment – I will accept this a good news – even though I know a new drug or vaccine will be coming down the pike to be prescribed to women with this severe disorder. Helluva lucrative market right? Millions of women – and millions of dollars to be gained on our suffering from the environmental endocrine disruptors that have screwed with our body in the first place – including hormonal birth control.

But yes, anything to help the women who are miserable – while the rest of us start figuring out how to undo the environmental damage.

“For the first time, we now have cellular evidence of abnormal signalling in cells derived from women with PMDD, and a plausible biological cause for their abnormal behavioural sensitivity to estrogen and progesterone,” commented Dr Peter Schmidt, of the NIH’s National Institute of Mental Health, Behavioural Endocrinology Branch.

PMDD: Severe form of PMS affecting women’s mental health ‘linked to cell disorder’

Scientists have linked premenstrual dysphoric disorder with how cells process sex hormones

January 3, 2017

Kashmira Gander

A severe form of premenstrual syndrome (PMS) which negatively affects a woman’s mood may be caused by a cellular disorder, according to a new study.

Women with the little understood but debilitating condition known as premenstrual dysphoric disorder (PMDD) are more likely to experience feelings of anxiety, sadness, and irritability in the days before their periods. Psychical symptoms include changes in appetite, cramps, bloating, headaches, hot flashes, breast tenderness, and joint and muscle pain.

Between two and five per cent of women of child-bearing age have PMDD, compared with four in 10 women who suffer from PMS.

Researchers at the National Institutes of Health (NIH) found that women with PMDD are more sensitive to the effects of sex hormones estrogen and progesterone, due to a molecular mechanism in their genes.

The team behind the research hopes that shedding light into the complex role of genes in PMDD will help to treat women with mood disorders linked to reproduction.

“This is a big moment for women’s health, because it establishes that women with PMDD have an intrinsic difference in their molecular apparatus for response to sex hormones – not just emotional behaviours they should be able to voluntarily control,” said Dr David Goldman of the NIH’s National Institute on Alcohol Abuse and Alcoholism, and colleagues.

Read full article…


Author: Leslie Carol Botha

Author, publisher, radio talk show host and internationally recognized expert on women's hormone cycles. Social/political activist on Gardasil the HPV vaccine for adolescent girls. Co-author of "Understanding Your Mood, Mind and Hormone Cycle." Honorary advisory board member for the Foundation for the Study of Cycles and member of the Society for Menstrual Cycle Research.

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