Holy Hormones Journal: Are we done yet? Are we beginning to understand that messing with the motherboard (the brain) is dangerous – PERIOD? Let’s go through the list – and then you decide if the anti-inflammatory drugs you are is worth your being infertile, or prone to miscarriages – or heavy menstrual bleeding, cancer – or depression/anxiety or other social phobias, or weight gain. These are just some of pathologies that present when progesterone levels are low. No wonder the IVF industry is booming.
And then of course, if you manage to get pregnant – you just hand this imbalance over to your baby – like handing a baton over in a relay race…and the race continues until the epigenetic damage catches up and takes down the runner. We are not called the human race for nothing. Seriously though, we are in a race with our lives and the health of future generations.
Just in case you wondered these drugs are not even considered safe during pregnancy. Yet so many women are unaware of the detrimental effects these over-the-counters medications can have on the health of the baby.
Non-steroidal anti-inflammatory drugs (NSAIDs) are chemically heterogeneous groups of compounds which nevertheless share certain common therapeutic actions and adverse effects. The most commonly used NSAIDs are aspirin, acetaminophen, Ibuprofen, diclofenac, indometacin and naproxen. All NSAIDs share antipyretic, analgesic and anti-inflammatory actions with the exception of acetaminophen which is antipyretic and analgesic but is largely devoid of anti-inflammatory activity.[1–3] Non-steroidal anti-inflammatory drugs are among the widely used drugs and are often used by pregnant women especially during first trimester of pregnancy.
Virtually, all currently available NSAIDs can have significant unwanted effects. Several previous studies[7–9] showed that NSAIDs use on late pregnancy can be associated with severe adverse neonatal outcomes including increased risks of premature closure, persistent fetal pulmonary hypertension, increased risk of congenital heart defects, intracranial hemorrhages, renal toxicity in fetus, and orofacial clefts.
~North American Journal of Medical Sciences
Non-steroidal anti-inflammatory drugs inhibit ovulation after just 10 days
Date: June 11, 2015
Source:European League Against RheumatismSummary:
The results of a new study show that diclofenac, naproxen and etoricoxib significantly inhibit ovulation in women with mild musculoskeletal pain. Of the women receiving NSAIDs, only 6.3 percent (diclofenac), 25 percent (naproxen) and 27.3 percent (etoricoxib) ovulated, compared with 100 percent of the control group.
The results of a study presented today at the European League Against Rheumatism Annual Congress (EULAR 2015) show that diclofenac, naproxen and etoricoxib significantly inhibit ovulation in women with mild musculoskeletal pain. Of the women receiving NSAIDs, only 6.3 percent (diclofenac), 25 percent (naproxen) and 27.3 percent (etoricoxib) ovulated, compared with 100 percent of the control group.
These findings suggest that readily available non-steroidal anti-inflammatory drugs (NSAIDs) could have a harmful effect on fertility, and should be used with caution in women wishing to start a family.
‘After just ten days of treatment we saw a significant decrease in progesterone, a hormone essential for ovulation, across all treatment groups, as well as functional cysts in one third of patients,’ said study investigator Professor Sami Salman, Department of Rheumatology, University of Baghdad, Iraq. ‘These findings show that even short-term use of these popular, over-the-counter drugs could have a significant impact on a women’s ability to have children. This needs to be better communicated to patients with rheumatic diseases, who may take these drugs on a regular basis with little awareness of the impact.’
NSAIDs are among the most commonly used drugs worldwide, and are taken by more than 30 million people every day. Available without prescription, NSAIDS are largely used for the treatment of pain, inflammation and fever — all common features of rheumatic conditions.