Transmission of Cervical Cancer-Associated Human Papilloma Viruses from Mother to Child
Posted in: Human Papillomavirus, - size 192.56 kBDocument provides information on non-sexual contact HPV transmission. Pre-exsiting HPV conditions nullify vaccine effectiveness and can actually increase risk of cervical cancer in those who receive the shot.
The Case for Cycles
Posted in: Natural Cycles, - size 856.8 kBFirst published by the Foundation for the Study of Cycles in the magazine Cycles in July 1967 "There is considerable evidence, as we shall see in the pages that follow, that there are natural environmental forces that alternately stimulate and depress mankind in the mass. These same forces may also affect plant and animal life, weather, and even such normally unchanging things as chemical reactions.
Moon Awareness Guide
Posted in: Natural Cycles, - size 118.53 kBThe Moon circles the earth roughly every 28 days. Earth is moving as well so it takes about 29 1/2 days for the moon to reach the same point in the sky as the month before (a lunation). A moon cycle consists of eight phases. Each phase lasts about 3 1/2 days. The moon phases affect ocean tides, plants, and humans. Here's how the moon affects you:
GlaxoSmithKline’s Cervical Cancer Candidate Vaccine
Posted in: Vaccines, - size 81.52 kBGlaxoSmithKline’s (GSK) cervical cancer candidate vaccine is currently undergoing clinical trials to determine its efficacy and safety in protecting women from cervical cancer. The candidate vaccine targets the cancer-causing human papillomavirus types 16 and 18, which are responsible for at least 70 percent of all cervical cancer cases worldwide.
Australian Doc Refuting Gardasil
Posted in: Gardasil, - size 210.4 kBQuadrivalent HPV vaccination reactions More hype than harm Background The quadrivalent human papillomavirus (HPV) vaccine Gardasil was licensed for use in June 2006. Since its approval more than 26 million doses of the vaccine have been distributed worldwide. There is ongoing debate as to the safety of the vaccine, with suggestions of a link between the vaccine and syncopal events, and the aetiology of more chronic conditions such as Guillain-Barre syndrome. Objective A case of subcutaneous emphysema secondary to quadrivalent HPV vaccination is described, and reported adverse events to quadrivalent HPV vaccination in both Australia and the United States are examined. Discussion On the basis of published peer reviewed literature, and from data analysis conducted by reputable agencies, the conclusion is drawn that adverse events are mild and self limiting and quadrivalent HPV vaccine is safe when administered according to the manufacturer’s recommendations.
Patient Information about GARDASIL® (pronounced “gard-Ah-sill”)
Posted in: Human Papillomavirus Vaccine, - size 32.78 kBGeneric name: [Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) Vaccine, Recombinant] Read this information with care before getting GARDASIL‚àó. You (the person getting GARDASIL) will need 3 doses of the vaccine. It is important to read this leaflet when you get each dose. This leaflet does not take the place of talking with your health care provider about GARDASIL.
Suspected Adverse Reaction Analysis - Cervarix
Posted in: Human Papillomavirus Vaccine, - size 534.7 kBCERVARIX Human papillomavirus (HPV) vaccine 2 July 2009 - from MHRA This report summarises the adverse reactions suspected to have been caused by Cervarix human papillomavirus (HPV) vaccine in the UK. This includes reports received between 14 April 2008 and 1 July 2009. These reports have been voluntarily submitted to the MHRA (Medicines and Healthcare products Regulatory Agency) by healthcare professionals and members of the public via the Yellow Card Scheme (visit www.yellowcard.gov.uk) and by the manufacturers of the vaccine as part of their legal requirements.
Suspected Adverse Reaction Analysis -Human papillomavirus (HPV) vaccine (brand unspecified)
Posted in: Human Papillomavirus Vaccine, - size 227.63 kBJuly 2, 2009 - This report summarises the reports of adverse reactions suspected to have been caused by human papillomavirus (HPV) vaccine for which information on the specific brand administered (whether Cervarix or Gardasil) is currently unavailable. This includes reports received up to 1 July 2009. Separate Adverse Reaction Analysis summaries exist for reports in which the brand was stated. These reports have been voluntarily submitted to the MHRA (This report summarises the reports of adverse reactions suspected to have been caused by human papillomavirus (HPV) vaccine for which information on the specific brand administered (whether Cervarix or Gardasil) is currently unavailable. This includes reports received up to 1 July 2009. Separate Adverse Reaction Analysis summaries exist for reports in which the brand was stated. These reports have been voluntarily submitted to the MHRA (Medicines and Healthcare products Regulatory Agency) by healthcare professionals and members of the public via the Yellow Card Scheme (visit www.yellowcard.gov.uk) and by the manufacturers of the vaccine as part of their legal requirements.
Vaccination against cervical cancer
Posted in: Human Papillomavirus Vaccine, - size 304.83 kBTo the Minister of Health, Medicine and Sport, Netherlands Subject : Presentation of advisory report Vaccination against cervical cancer Your reference : PG/ZP-2.746.254 Our reference : I-191/AK/KG/cn/831-E Enclosure(s) : 1 Date :March 31, 2008
Ovulatory cycle effects on tip earnings of lap dancers
Posted in: Hormones, - size 195.85 kBTo see whether estrus was really lost during human evolution.
International Swine Flu Conference
Posted in: Vaccines, - size 183.88 kBAugust 19 - 20, 2009 Washington DC
Baxter H5N1 Vaccine Development and Evaluation
Posted in: Vaccines, - size 548.51 kBWHO Meeting on Development and Evaluation of Influenza Pandemic Vaccines Geneva, November 2 - 3, 2005 Proof is in the pudding. Swine Flu vaccine developed prior to so-called pandemic.
HPV Vaccination Mandate for Immigrant Women and Girls
Posted in: Gardasil, - size 164.8 kBThe undersigned, over 140 immigrants’ rights, women’s rights, public health, medical, and reproductive justice organizations write to urge the CDC to act quickly and finalize the proposed criteria for identifying Advisory Committee on Immunization Practices (ACIP) recommended vaccines as immunization requirements for immigrants.
Thimerosal exposure in infants and neurodevelopmental disorders:
Posted in: Vaccines, - size 204.33 kBAn assessment of computerized medical records in the Vaccine Safety Datalink
The Risks and Benefits of HPV Vaccination
Posted in: Human Papillomavirus Vaccine, - size 50.26 kBJAMA - Charlotte Haug, MD, PhD, MSc WHEN DO PHYSICIANS KNOW ENOUGH ABOUT THE beneficial effects of a new medical intervention to start recommending or using it? When is the available information about harmful adverse effects sufficient to conclude that the risks outweigh the potential benefits?
Marketing HPV Vaccine Implications for Adolescent Health and Medical Professionalism
Posted in: Human Papillomavirus Vaccine, - size 121.73 kBSheila M. Rothman, PhD David J. Rothman, PhD IN PROMOTING ADOLESCENT HEALTH, immunization is frequently a costeffective intervention, advancing “not only the functioning and opportunities of adolescents themselves, but also the quality of their adult lives.”1
Postlicensure Safety Surveillance for Quadrivalent Human Papillomavirus Recombinant Vaccine
Posted in: Human Papillomavirus Vaccine, - size 159.24 kBBarbara A. Slade, MD, MS Laura Leidel, RN, FNP-C, MPH Claudia Vellozzi, MD, MPH Emily Jane Woo, MD, MPH Wei Hua, MD, PhD Andrea Sutherland, MD, MSc, MPH Hector S. Izurieta, MD, MPH Robert Ball, MD, MPH Nancy Miller, MD M. Miles Braun, MD, MPH Lauri E. Markowitz, MD John Iskander, MD ON JUNE 8, 2006, THE FOOD and Drug Administration (FDA) licensed the quadrivalent human papillomavirus recombinant vaccine (qHPV) (Gardasil; Merck & Co, Inc, Whitehouse Station, New Jersey) for females aged 9 to 26 years to prevent infection with genital human papillomavirus (HPV) types 6, 11, 16, and 18.1
Vertical transmission of the human papillomavirus: a systematic quantitative review
Posted in: Human Papillomavirus, - size 324.71 kBTransmissão vertical do papilomavírus humano: uma revisão sistemática quantitativa The association between sexual activity and cervical cancer has been known. It is also well recognized that high-risk HPV is spread by sexual activity 1. There is growing evidence that HPV infection is acquired through non-sexual routes, and that one potential route is motherto- child transmission in the perinatal period 5,6,7,8. Although epidemiological trials suggest the possibility of non-sexual transmission, there is evidence of vertical transmission, presumably occurring during passage of the fetus through an infected birth canal.
Neuroimmunology of Autism Spectrum Disorder
Posted in: Neurology, - size 69.75 kBNeuroScience Institute White Paper Autism is a developmental disorder characterized by immunological and neurological abnormalities. The role of cytokines in the pathophysiology of autism has been researched suggesting a relationship with altered blood-brain barrier permeability and subsequent neuroinflammation. Cytokine recruitment to the CNS may result in altered neurotransmitter signaling and the behavioral manifestation of autism symptoms. Other immune mediated events such as changes in the number and activity of natural killer cells, macrophages, immunoglobulins, and glutathione may contribute to altered neuronal signaling and neurotransmitter imbalances. The purpose of this overview is to examine the relationship between immune system and nervous system dysfunction to determine biomarkers for autism spectrum disorder. We will explore the utility of serum cytokines and urinary neurotransmitter analyses as biomarkers for autism.
ALLIANCE FOR NATURAL HEALTH CALL FOR AN URGENT SCIENTIFIC INQUIRY INTO THE HPV VACCINE USED IN THE UK
Posted in: Human Papillomavirus Vaccine, - size 150.73 kBThe Alliance for Natural Health today is calling on all Members of Parliament in the UK to help stimulate an independent and transparent scientific inquiry on thesafety of the HPV vaccine.
Effects of Expectancies on Women's Reports of Moods During the Menstrual Cycle
Posted in: Hormones, - size 1.69 MBBARBARA OLASOV, MS AND JOAN JACKSON, PHD Social expectancies are assumed by many researchers to influence the reporting of menstrual and premenstrual symptoms. This study investigated the role of expectancies by attempting to manipulate college women's expectancies for a negative mood-menstrual relationship and observing the effect on self-reported daily moods. One group of women viewed a videotaped lecture designed to increase expectancies for a negative mood-menstrual relationship while a second group viewed a lecture designed to decrease such expectancies. A third group was exposed to a lecture on an unrelated topic, and a fourth, blind control group was neither exposed to a lecture nor aware that the study was concerned with the menstrual cycle. Expectancies were assessed immediately before and after presentation of the lectures. In addition, all participants monitored their moods for 40 consecutive days, after which expectancies were reassessed. Results indicated that expectancies were altered in the predicted directions by the experimental manipulations, with group differences apparent even at the 40 day follow-up. Even more importantly, daily moods during the course of the menstrual cycle were also affected by the manipulations, thus supporting the importance of expectancies as a determinant of mood.
One Less Yes for Gardasil
Posted in: Human Papillomavirus Vaccine, - size 204.64 kBCelebrate Life - by Lisa Bastian In 2006, the U.S. Food and Drug Administration approved Gardasil, the first-ever vaccine for females 9 to 26 years old, designed to prevent just 4 of the over 100 strains of the human papillomavirus. Only two percent of undiagnosed HPV infections lead to cervical cancer, a rare form of cancer.
Chronobiological Basis of Female-Specific Mood Disorders
Posted in: Hormones, - size 102.17 kBBarbara L. Parry, M.D., and Ruth P. Newton, Ph.D. Women have twice the incidence of major depression compared with men. They are prone to develop episodes of depression during times of reproductive hormonal change at puberty, with use of oral contraceptives, during the premenstrual phase of the menstrual cycle, postpartum and during the perimenopause (see review: Parry 1995a). Wirz- Justice (1995) describes the variety of disturbances in biological rhythms observed in mood disorders. In this report, we describe the chronobiological disturbances observed in female-specific mood disorders, namely, premenstrual dysphoric disorder, pregnancy and postpartum depression and menopause. We hypothesize that changing reproductive hormones, by affecting the synchrony or coherence between components of the circadian system, may alter amplitude or phase (timing) relationships and thereby contribute to the development of mood disorders in predisposed individuals. [Neuropsychopharmacology 25:S102–S108, 2001] © 2001 American College of Neuropsychopharmacology.
Holy Hormones Honey! Personal Cycle Journal from Menarche to Menopause
Posted in: Hormones, - size 114.7 kBMark your symptoms/feelings for each day of your cycle and watch your cyclical nature unfold! Fill in each category with the symptoms and /or behaviors that you would like to chart. Menstruating women watch your hormonal changes in relation to the day of your cycle and the lunar cycle. Menopausal women watch your changes in relation to the lunar cycle. Honor your cyclical Nature – It is the foundation of your being.
Hormone Cycle Attitude Questionnaire
Posted in: Hormones, - size 73.75 kBUnderstanding your body through “the whole picture of health”® is crucial to your healing process. When women feel discomfort during their menstrual cycle we generally attribute the negative physical experience solely to the “negatively induced” physical nature of menstruation and reach for a quick remedy to ease the distress and anxiety. These remedies can span from conservative pain relievers, to hormone regulators and for many of us, hysterectomies. What would serve us in resolving these imbalances is to more fully understand the different facets of our health, which contribute to our menstrual difficulties -apart from the obvious physical one.
Suspected Adverse Reaction Analysis - Cervarix II
Posted in: Human Papillomavirus Vaccine, - size 112.68 kBThis report summarises the adverse reactions suspected to have been caused by Cervarix human papillomavirus (HPV) vaccine in the UK. This includes reports received between 14 April 2008 and 2 December 2009. These reports have been voluntarily submitted to the MHRA by healthcare professionals and members of the public via the Yellow Card Scheme (visit HTUTUwww.yellowcard.gov.ukUTH) and by the manufacturers of the vaccine as part of their legal requirements.
Suspected Adverse Reaction Analysis - HPV Vaccine Brand Unspecified
Posted in: Human Papillomavirus Vaccine, - size 72.22 kBMHRA -This report summarises the reports of adverse reactions suspected to have been caused by human papillomavirus (HPV) vaccine for which information on the specific brand administered (whether Cervarix or Gardasil) is currently unavailable. This includes reports received up to 02 December 2009. Separate Adverse Reaction Analysis summaries exist for reports in which the brand was stated. These reports have been voluntarily submitted to the MHRA by healthcare professionals and members of the public via the Yellow Card Scheme (visit www.yellowcard.gov.uk) and by the manufacturers of the vaccine as part of their legal requirements.
The Pineal Gland and the Ancient Art of Iatromathematica
Posted in: Hormones, - size 253.98 kBFRANK MCGILLION1 12 Whitley Court, 84 Westmoreland Road, Bromley, Kent, BR2 0QT, England e-mail: [email protected] Abstract—The medical astrologers of Ancient Greece: the iatromathematici, and the later European physician-astrologers, assumed a correlation between events in the heavens and those on earth that was relevant to both health and disease. Some of the early practitioners of modern scientific medicine did the same under the aegis of what we might term, proto-cosmobiology, though none could provide an adequate mechanism to explain the nature of the link they believed existed between the skies and ourselves.
Pregnancy Outcomes From the Pregnancy Registry of a Human Papillomavirus Type 6/11/16/18 Vaccine
Posted in: Gardasil, - size 268.53 kBAdrian Dana, MD, Karyn M. Buchanan, BSN, Mary Ann Goss, MSN, Margaret M. Seminack, BSN, Kristine E. Shields, MSN, MPH, Scott Korn, MD, Michael L. Cunningham, MD, PhD, and Richard M. Haupt, MD, MPH OBJECTIVE: To better describe the safety profile of pregnancy exposures to the human papillomavirus (HPV) type 6/11/16/18 vaccine by acquiring and analyzing post marketing data on pregnancy outcomes (ie, live births, abortions, fetal deaths, and congenital anomalies).
Update on Quadrivalent Human Papillomavirus Vaccination and Pregnancy Outcomes
Posted in: Human Papillomavirus Vaccine, - size 132.08 kBIs Contraception Advisable? Current guidelines from the Centers for Disease Control and Prevention recommend prophylactic quadrivalent human papillomavirus (HPV) types 6/11/16/18 vaccination of women up to the age of 26 years, a population with childbearing potential. While the vaccine is not recommended for use in pregnant women, inadvertent exposures during pregnancy do occur. Therefore, clinicians and patients will be interested in two articles in this issue of Obstetrics & Gynecology that report pregnancy outcomes among women who received HPV vaccination within 30 days of conception, at any time during pregnancy, or at any time during phase III vaccine trials.
Suspected Adverse Reaction Analysis CERVARIX Human papillomavirus (HPV) vaccine 7 January 2010
Posted in: Human Papillomavirus Vaccine, - size 115.95 kBThis report summarises the adverse reactions suspected to have been caused by Cervarix human papillomavirus (HPV) vaccine in the UK. This includes reports received between 14 April 2008 and 6 January 2010. These reports have been voluntarily submitted to the MHRA by healthcare professionals and members of the public via the Yellow Card Scheme (visit HTUTUwww.yellowcard.gov.ukUTH) and by the manufacturers of the vaccine as part of their legal requirements. It is essential to bear in mind that reports to the MHRA relate only to adverse medical events which the reporter considered could have been caused by the vaccine (i.e. if there was merely a suspicion of causality). Therefore, cases may be true side-effects or they may have been purely coincidental events due to underlying or undiagnosed illness that would have occurred anyway in the absence of vaccination. Events may also have been psychogenicTPTP 1 PTPT in origin. This report therefore cannot be considered to represent a list of known side-effects of the vaccine. These data also cannot be used to determine the frequency, or incidence, of known side-effects because they are often under-reported. The known side-effects, and their frequencies (based on clinical trial data), are available in the product information (see HTUTUhttp://emc.medicines.org.uk/UTH).
Suspected Adverse Reaction Analysis Human papillomavirus (HPV) vaccine (brand unspecified) 7 January 2010
Posted in: Human Papillomavirus Vaccine, - size 71.6 kBThis report summarises the adverse reactions suspected to have been caused by Cervarix human papillomavirus (HPV) vaccine in the UK. This includes reports received between 14 April 2008 and 6 January 2010. These reports have been voluntarily submitted to the MHRA by healthcare professionals and members of the public via the Yellow Card Scheme (visit HTUTUwww.yellowcard.gov.ukUTH) and by the manufacturers of the vaccine as part of their legal requirements. It is essential to bear in mind that reports to the MHRA relate only to adverse medical events which the reporter considered could have been caused by the vaccine (i.e. if there was merely a suspicion of causality). Therefore, cases may be true side-effects or they may have been purely coincidental events due to underlying or undiagnosed illness that would have occurred anyway in the absence of vaccination. Events may also have been psychogenicTPTP 1 PTPT in origin. This report therefore cannot be considered to represent a list of known side-effects of the vaccine. These data also cannot be used to determine the frequency, or incidence, of known side-effects because they are often under-reported. The known side-effects, and their frequencies (based on clinical trial data), are available in the product information (see HTUTUhttp://emc.medicines.org.uk/UTH).
Adverse Events and Quadrivalent Human Papillomavirus Recombinant Vaccine (1)
Posted in: Human Papillomavirus Vaccine, - size 55.93 kBLetters to the Editor JAMA December 23/30 2009 Adverse Events and Quadrivalent Human Papillomavirus Recombinant Vaccine To the Editor: Dr Slade and colleagues1 evaluated reports submitted to the Vaccine Adverse Event Reporting System (VAERS) for quadrivalent human papillomavirus recombinant vaccine (qHPV). Federal officials have cited this study as evidence that qHPV “is a safe and effective vaccine.”2 However, we consider that conclusion to be unwarranted because the study draws inferences from data likely to be systematically biased, and because the design of the study cannot disprove causal associations at the individual level.
Adverse Events and Quadrivalent Human Papillomavirus Recombinant Vaccine (2)
Posted in: Human Papillomavirus Vaccine, - size 66.7 kBJAMA December 23/30 2009 Letter to the Editor Efficacy Data and HPV Vaccination Studies To the Editor: In her Editorial on the risks and benefits of human papillomavirus (HPV) vaccination, Dr Haug statedthat data on vaccine efficacy, as measured by prevention of precancerous lesions (cervical intraepithelial neoplasias grades 2 and 3 [CIN 2/3]), were not reported until May 2007.1 That would have been almost a year after the US Food and Drug Administration (FDA) licensed the vaccine and the Centers for Disease Control and Prevention (CDC) Advisory Committee on Immunization Practices (ACIP) recommended routine vaccination of girls aged 11 to 12 years. She also noted that professional medical associations provided members with educational materials more than a year before the data on the important end point of CIN 2/3 were published.
Adverse Events and Quadrivalent Human Papillomavirus Recombinant Vaccine (3)
Posted in: Human Papillomavirus Vaccine, - size 56.9 kBLetter to the Editor Marketing and the HPV Vaccine Jama December 23/30, 2009 To the Editor: I would like to respond to the Special Communication on marketing human papillomavirus (HPV) vaccine by Drs Rothman and Rothman.1 Vaccination against the most virulent types of HPV is an extremely valuable innovation. The current cervical cancer prevention system is effective but expensive, intrusive, nonspecific, and statistically insensitive.2 Clinicians in the United States treat thousands of women each year with HPV disease fated to regress, with consequent monetary and emotional costs, procedure-related injuries, and perinatal morbidity due to cervical compromise.3,4 Human papillomavirus is the cause of cervical cancer. The US Food and Drug Administration (FDA) has approved HPV vaccination as safe and effective, reflecting the opinion of cervical cancer experts that vaccination will decrease the burden of not only cervical cancer, but also precancer, with fewer abnormal Pap test results colposcopies, and cervical treatments.
Brief Assessment of Aluminum Exposure and Endocrine Disruption
Posted in: Environmental Toxins, - size 21.97 kBDan R Laks, M.S. UCLA Neuroscience Research Center 6/21/09 ...It is thought that inflammation resulting from aluminum exposure may induce learning and memory deficits[39]. Certainly, targeted effects on the endocrine system may affect immune-modulation and produce a pro-inflammatory cascade that responds to targeted aluminum deposition in the hippocampus with resultant neurotoxicity.
Assessment of chronic mercury exposure within the U.S. population, National Health and Nutrition Examination Survey, 1999–2006
Posted in: Environmental Toxins, - size 334.26 kBDan R. Laks Mental Retardation Research Center, David Geffen School of Medicine at UCLA, 635 Charles E. Young Dr. South, Neuroscience Research Bldg., Room 379 (lab), Los Angeles, CA 90095-7332, USA Received: 22 February 2009 /Accepted: 10 August 2009 Springer Science+Business Media, LLC. 2009 ...Furthermore, multivariate logistic regression revealed significant associations of both I-Hg detection and mean concentration with biomarkers for the main targets of mercury deposition and effect: the liver, immune system, and pituitary. This study provides compelling evidence that I-Hg deposition within the human body is a cumulative process, increasing with age and in the population over time, since 1999, as a result of chronic mercury exposure.
A 16-Year-Old Girl With Bilateral Visual Loss and Left Hemiparesis Following an Immunization
Posted in: Gardasil, - size 609.37 kBFrancis J. DiMario, Jr, MD, Mirna Hajjar, MD, and Thomas Ciesielski, MD Journal of Child Neurology Volume 25 Number 3 March 2010 321-327 # 2010 The Author(s) 10.1177/0883073809349322 http://jcn.sagepub.com We report the course of a 16-year-old girl who presented with near complete visual loss associated with chiasmal neuritis and a biopsy proven tumefactive demyelinating lesion on magnetic resonance imaging (MRI) in association with a recent immunization against human papilloma virus.
USPPI Patient Information about GARDASIL® (pronounced “gard-Ah-sill”) Generic name: [Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) Vaccine, Recombinant]
Posted in: Gardasil, - size 44.41 kBOctober 2009 What are the possible side effects of GARDASIL? The most common side effects with GARDASIL are: • pain, swelling, itching, bruising, and redness at the injection site • headache • fever • nausea • dizziness • vomiting • fainting Tell your health care provider if you have any of the following problems because these may be signs of an allergic reaction: • difficulty breathing • wheezing (bronchospasm) • hives • rash Tell your health care provider if you have: • swollen glands (neck, armpit, or groin) • joint pain • unusual tiredness, weakness, or confusion • chills • generally feeling unwell • leg pain • shortness of breath • chest pain • aching muscles • muscle weakness • seizure • bad stomach ache • bleeding or bruising more easily than normal Contact your health care provider right away if you get any symptoms that concern you, even several months after getting the vaccine.
Multiple Evanescent White Dot Syndrome After Vaccination for Human Papilloma Virus and Meningococcus
Posted in: Human Papillomavirus, - size 953.81 kBSteven M. Cohen, MD ABSTRACT Multiple evanescent white dot syndrome is a rare chorioretinopathy causing transitory vision loss, usually in females and generally in one eye. In 2007, widespread vaccination of older children against human papilloma virus and meningococcus was recommended by the Centers for Disease Control and Prevention. A 17-year-old girl presented with multiple evanescent white dot syndrome 1 month after receiving these two vaccinations. [J Pediatr Ophthalmol Strabismus 200X;XX:XX-XX.]
Gardasil®: When a Placebo is Not a Placebo
Posted in: Gardasil, - size 300.39 kBBy Hilary and Peter Butler from their book From One Prick To Another, (2008). ...In the case of Gardasil®, the researchers did not use an inert placebo. Components of the vaccine (like aluminium) were used, except the HPV parts. A very small subset of people were given saline. With the rotavirus vaccine, everything in the vaccine (except the virus), including Vero substrate cells, was used as a “placebo”.
Hormone Allergy
Posted in: Hormones, - size 130.11 kBRussell R. Roby, Richard H. Richardson, Aristo Vojdani Roby Institute, Austin, TX, USA Background Estrogen and progesterone have been associated in women with symptoms that include asthma, migraine, dermatitis and pain. Objective We suggest a connection between symptoms associated with hormone changes to a hormone antibody response.
Heavy Metals and Fertility
Posted in: Environmental Toxins, - size 667.47 kBIngrid Gerhard, Bondo Monga, Andreas Waldbrenner, Benno Runnebaum Department of Gynecological Endocrinology and Reproduction, University Hospital of Obstetrics and Gynaecology, Heidelberg, Germany Journal of Toxicology and Environmental Health, Part A, 54:593–611, 1998 Copyright © 1998 Taylor & Francis Heavy metals have been identified as factors affecting human fertility. This study was designed to investigate whether the urinary heavy metal excretion is associated with different factors of infertility.
NATO Advanced Study Institute on Immunological Adjuvants and Vaccines
Posted in: Environmental Toxins, - size 6.2 MB1988 : Akra Sounion, Greece New York : Plenum Press, c1989. viii, 244 p. : ill. ; 26 cm. "Proceedings of a NATO Advanced Study Institute on Immunological Adjuvants and Vaccines, held June 24-July 5, 1988, in Cape Sounion Beach, Greece"--T.p. verso. "Published in cooperation with NATO Scientific Affairs Division." Excerpt - On page 37 of this NATO book, it states that studies demonstrate that “aluminum causes stimulation of the production of anaphylactic antibody (IgE) in the mouse”, and that “the effect of aluminum on the IgE response in humans does not appear to have been investigated”.
Global Parental Concerns About HPV Vaccines - 3.12 FDA Presentation
Posted in: Gardasil, - size 70.01 kBPresented by: Rosemary Mathis, North Carolina - VAERS Research [email protected] Leslie C Botha, Colorado – Women’s Health Activist; Broadcast Journalist [email protected] Freda Birrell, Scotland/UK – Political Activist [email protected] Janny Stokvis , Netherlands - Research Analyst [email protected] Karen Maynor, New Mexico – Political Activist [email protected] Cynthia Janak, Illinois – Research Journalist [email protected] Full Webinar Documents at http://truthaboutgardasil.org
Routine Testing Confirms Elevated Male Hormones in Autism
Posted in: Gardasil, - size 107.76 kBNovember 2007 WASHINGTON, DC – A new moderate-scale peer-reviewed scientific/medical study confirms many patients with an autistic spectrum disorder (ASD) suffer from significantly elevated levels of male hormones, and numerous treatments that lower male-hormone levels have significantly improved clinical outcomes in patients with an ASD.
Dietary Supplements Reduce the Risk of Cervical Intraepithelial Neoplasia
Posted in: Human Papillomavirus, - size 587.07 kBJong Ha Hwang,* Mi Kyung Kim,√û and Jae Kwan Lee* Objective: To examine the effects of dietary supplements on high-risk human papillomavirus (HPV) infection and cervical carcinogenesis. Methods: A multi-institutional cross-sectional study was carried out to examine whether dietary supplements were associated with the risk of cervical intraepithelial neoplasia (CIN).
Opsoclonusmyoclonus after human papilloma virus vaccine in a pediatric patientq
Posted in: Gardasil, - size 94.76 kBThe patient was a fully vaccinated and developmentally appropriate 11-year-old female with seasonal allergies and mild asthma. Her initial symptoms consisted of a sudden onset of increased ‘‘moodiness’’ causing uncharacteristic anger and depression. These symptoms presented approximately 15 days after receiving her first human papilloma virus (HPV) (Gardisil) vaccination on 11/26/2007.
ACUTE DISSEMINATED ENCEPHALOMYELITIS FOLLOWING VACCINATION AGAINST HUMAN PAPILLOMA VIRUS
Posted in: Gardasil, - size 301.78 kBCase report. A 20-year-old woman developed headache, nausea, vomiting, and diplopia within 28 days of the second immunization with the quadrivalent HPV vaccine Gardasil®. She did not report signs of a preceding infection.
A Fact Sheet on the Risk of Cervical Cancer and Use of Gardasil® Vaccine
Posted in: Gardasil, - size 674.37 kBAustralian Vaccination Network - Facts about the Disease • In 2004, the death rate from cervical cancer in Australia was 1.9/100,000 women. This represents a very low risk to Australian women • Infection with Human Papillomavirus (HPV) is not an indication you will get cervical cancer • HPV is a common infection in women (75%) but it uncommonly progresses to cancer • The lifetime risk of dying from cervical cancer in developed country like Australia is 0.25%
Abnormal Pap tests after the HPV vaccine
Posted in: Human Papillomavirus, - size 137.99 kBAFP - Australian Family Physician Vol 38, (12) 977-979 Stella Heley BA(Hons), MBBS, FAChSHM, is Senior Liaison Physician, Victorian Cytology Service, Melbourne, Victoria. Julia Brotherton BMed(Hons), MPH(Hons), GradDipAppEpi, FAFPHM, is an epidemiologist, National HPV Vaccination Program Register, Victorian Cervical Cytology Registry, Victorian Cytology Service, Melbourne, Victoria. BACKGROUND Worldwide, cervical cancer affects 500 000 women and causes 275 000 deaths annually. Persistent infection with one of 13 oncogenic types of human papillomavirus (HPV) is now known to be the cause of both squamous and adenocervical carcinomas of the cervix. The Pap test involves the examination of exfoliated cells from the cervix and has been shown to be an effective way of detecting the precursors of squamous cell carcinoma. In Australia, commencing in 2007, a free quadrivalent HPV vaccine was offered to all females aged 12–26 years.
The dangerous impurities of vaccines,
Posted in: Vaccines, - size 166.41 kBEmail: [email protected], www.fearoftheinvisibe.com Abstract In 1998 and 1999 scientists representing the World Health Organization (WHO) met with the senior vaccine regulatory scientists of the USA and UK at the National Institutes of Health (NIH) in Washington D.C. to discuss the safety of the manufacturing methods employed to produce vaccines. No journalists were present but official transcripts were kept. What they record is that all the many experts that spoke expressed grave concern over the safety of the manufacturing process currently employed to make the licensed vaccines, such as MMR, flu, yellow fever, and polio. It was reported by leading experts that the vaccines could not be purified, were “primitive,” made on “crude materials,” and the manufacturers could not meet lowered government standards.
Vaccine Exposures to Thimerosal (Mercury) & Premature Puberty
Posted in: Vaccines, - size 42.26 kBCoMeD Inc. PRESS RELEASE CONTACTS: For Immediate Release CoMeD President [Rev. Lisa K. Sykes (Richmond, VA) May 1, 2010 WASHINGTON, DC – A new study, “Thimerosal Exposure & Increasing Trends of Premature Puberty in the Vaccine Safety Datalink”, published in the most recent issue of the peer-reviewed Indian Journal of Medical Research1, confirms a significant association in American children between an increasing rates of premature puberty and increasing exposure to mercury from Thimerosal-containing childhood vaccines.
Exogenous Estrogen Rapidly Attenuates Pulmonary Artery Vasoreactivity and Acute Hypoxic Pulmonary Vasoconstriction
Posted in: Hormones, - size 1.82 MBTim Lahm,* Paul R. Crisostomo,† Troy A. Markel,† Meijing Wang,† Yue Wang,† Brent Weil,† and Daniel R. Meldrum†‡§ *Division of Pulmonary, Allergy, Critical Care and Occupational Medicine, †Departments of Surgery, ‡Cellular and Integrative Physiology, and §Center for Immunobiology, Received 3 Jan 2008; first review completed 16 Jan 2008; accepted in final form 18 Feb 2008 ABSTRACT—Chronic estrogen exposure has been shown to affect pulmonary artery (PA) vasoreactivity. However, the immediate effects of exogenously administered 17"-estradiol (E2) on vasopressor-induced PA vasoconstriction and acute hypoxic pulmonary vasoconstriction (HPV) have not yet been investigated. We hypothesized that exogenously administered E2 attenuates PA vasoreactivity and acute HPV through a rapid mechanism.
Estradiol-induced attenuation of pulmonary hypertension is not associated with altered eNOS expression
Posted in: Hormones, - size 366.69 kBTHOMAS C. RESTA, NANCY L. KANAGY, AND BENJIMEN R. WALKER Vascular Physiology Group, Department of Cell Biology and Physiology, Health Sciences Center, University of New Mexico, Albuquerque, New Mexico 87131-5218 Received 6 April 2000; accepted in final form 27 July 2000 Studies in other vascular beds suggest estrogen exhibits antiatherogenic properties that are mediated in part by alterations in endothelial function (1; reviewed in Ref. 17), including enhanced synthesis of the vasodilator and antimitogenic factor nitric oxide (NO) (4, 17, 18, 21).
Thimerosal exposure & increasing trends of premature puberty in the vaccine safety datalink
Posted in: Vaccines, - size 367.23 kBIndian J Med Res 131, April 2010, pp 500-507 David A. Geier*,**, Heather A. Young+ & Mark R. Geier# Background & objectives: The US Agency for Toxic Substances and Disease Registry (ATSDR) reports that mercury (Hg) is a known endocrine disruptor and it adversely affects the steroid synthesis pathway in animals and humans, and may interact to enhance the risk for a child developing premature puberty. An association between premature puberty and exposure to Hg from thimerosal-containing vaccines (TCVs) was evaluated in computerized medical records within the Vaccine Safety Datalink (VSD).
Quantifying the possible cross-reactivity risk of an HPV16 vaccine
Posted in: Human Papillomavirus Vaccine, - size 219.22 kBDarja Kanduc Department of Biochemistry and Molecular Biology, University of Bari, Italy Correspondence to: D. Kanduc, Department Biochemistry and Molecular Biology, University of Bari, Bari 70126 – Italy. Telephone: 39 080 544 3321; Fax: 39 080 544 3321. Email: [email protected]; [email protected] (Received: March 18, 2009; accepted: May 5, 2009) Background: The potential adverse events associated with vaccination for infectious diseases underscore the need for effective analysis and definition of possible vaccine side effects. Using the HPV16 proteome as a model, we quantified the actual and theoretical risks of anti-HPV16 vaccination, and defined the potential disease spectrum derived from concomitant cross-reactions with the human organism.
Gardasil Access Program for Underdeveloped Countries
Posted in: Gardasil, - size 270.9 kBWhat is the GARDASIL Access Program? Merck pledged to donate at least 3 million doses of GARDASIL, its quadrivalent HPV vaccine, to qualifying organizations and institutions in eligible lowest income countries, where approximately 80% of the world's cervical cancer cases occur.
HPV Vaccine Mysteries
Posted in: Human Papillomavirus Vaccine, - size 152.98 kBBy Janine Roberts There are two licensed HPV vaccines in the world. Merck makes Gardasil. It contains proteins said to come originally from four different types of HPV. By early 2008 over 10 million doses had been distributed, three-quarters of these in the USA. It is thought to be earning the company over $1 billion a year – at $360 a course of three injections, far more than is charged for the common vaccines The other is Cervarix, made by Smith Klein Beecham, which is not yet licensed for use in the USA (as of May 2008). It contains proteins said to come from 2 different types of HPV. Both vaccines contain aluminium adjuvants. Both manufacturers recommend that women are still regularly scanned for cervical cancer – thus the vaccine does not save costs. In fact these scans give women far better protection than does the vaccine. On December 10th, a Nobel Prize will be awarded for finding HPV and proving its link to cervical cancer to Dr Harad zur Hausen. However this is a missing link in this – for he failed to find a way to persuade cells to make his virus.
Females and Sex Addiction: Myths and Diagnostic Implications
Posted in: Women\'s Issues, - size 229.8 kBMarnie C. Ferree 2001 Females experience with sexually compulsive behavior rarely receive the attention directed to males who act out.
2006 EMEA Document on Silgard
Posted in: Silgard, - size 519.59 kBSCIENTIFIC DISCUSSION 1. Introduction Human papillomavirus (HPV) infection is currently the most common sexually transmitted disease worldwide. By 5 years after sexual debut, ~50% of young women will have been infected with at least one of the 40 HPV types that preferentially infect the genitals. Thirteen of these HPV types are highly carcinogenic. Although a consistent picture of the epidemiology and pathogenesis of genital infections in women has developed during the past two decades, less is known about these infections in men. However, studies suggest a similar infection pattern in men, who are the most important vectors for transmission of HPV disease to women. The peak incidence of HPV infection occurs in young adults between the ages 16 and 23 years.
God’s Gift to Women: The Human Papillomavirus Vaccine
Posted in: Gardasil, - size 143.18 kBImmunity 25, 179–184, August 2006 ª2006 Elsevier Inc. DOI 10.1016/j.immuni.2006.08.002 Summary An Australian newspaper recently bestowed Ian Frazer the title of ‘‘God’s gift to women’’ for his research team’s part in developing a vaccine to help control cervical cancer. Here Frazer discusses this work and the science behind the vaccine.
Investigation into Anti-trust Violations by Sanofi-Pasteur and Merck
Posted in: Gardasil, - size 3.82 MBJuly 6,2010 Letter to requests FTC initiate an investigation into the discriminatory and anti-competitive practices of Sanofi-Pasteur and Merck in their marketing and sales of certain vaccines.
Effect of the Menstrual Cycle and Hormonal Contraceptives on Human Papillomavirus Detection in Young, Unscreened Women
Posted in: Human Papillomavirus, - size 506.29 kBAmerican College of Obstetricians and Gynecologists - July 2010 Channa E. Schmeink, MD, Leon F. Massuger, MD, PhD, Charlotte H. Lenselink, MD, PhD, Wim G. Quint, PhD, Willem J. Melchers, PhD, and Ruud L. Bekkers, MD, PhD OBJECTIVE: To estimate the effect of the menstrual cycle and oral contraceptive pill (OCP) use on the prevalence, incidence, and persistence of human papillomavirus (HPV).
From Human Papillomavirus to Cervical Cancer
Posted in: Human Papillomavirus, - size 1.24 MBAmerican College of Obstetricians and Gynecologists - July 2010 Mark Schiffman, MD, MPH, and Nicolas Wentzensen, MD, PhD Cervical cancer is one of the most common female malignancies worldwide; 80% of cases occur in low-resource regions.1,2 Screening programs have been very successful in the United States, Europe, and other regions able to achieve broad and sustained coverage. In the United States, the disease is controlled at an annual cost of billions of dollars representing a major commitment by patients and clinicians. In fact, cervical cancer screening and management of minor screening abnormalities are among the most time-consuming parts of some gynecology practices.
The India HPV-vaccine suspension
Posted in: Human Papillomavirus Vaccine, - size 109.1 kBThe Lancet August 21, 2010 In response to demands from advocacy groups, the Indian Government has suspended demonstration projects for HPV vaccination in Andhra Pradesh and Gujarat.1,2 The episode provides salutary lessons abouthow a lack of public confidence can amplify if not quickly addressed.
Immunization Graphs: Natural Infectious Disease Declines; Immunization Effectiveness; and Immunization Dangers
Posted in: Vaccines, - size 1.3 MBPrepared by: Raymond Obomsawin Ph.D. Senior Advisor – First Nations Centre National Aboriginal Health Organization October 2009 FIGURE SET I. Natural Infectious Disease Declines Preceding Public Immunization Efforts FIGURE SET II. Immunization Effectiveness FIGURE SET III. Immunization Dangers
HPV Vaccination Study - A Phase IV, randomised study to evaluate the immune responses of UK adolescent girls receiving Cervarix or Gardasil Human Papillomavirus vaccines
Posted in: Human Papillomavirus Vaccine, - size 118.83 kBHealth Protection Agency - Patient Information Leaflet Study code: HPV CSP01 Your doctors’ surgery or school is taking part in a study with the Health Protection Agency of two licensed HPV vaccines, one of which is being used in the routine UK schedule. Before you decide if you would like to join this study you need to understand the reasons the research is being done and what it would involve. Ask us if there is anything that is not clear or if you would like more information. We encourage you to discuss this leaflet with your parents and others to help you with your decision. It is important to take time to decide whether or not you wish to take part.
Report Concerning Survey of Adverse Events Following Inoculations with Gardasil
Posted in: Gardasil, - size 157.96 kBcopyright 2010 Emily Tarsell, LCPC and James Garrett, PhD February 18, 2010 Abstract Background The Food and Drug Administration (FDA) concluded that the rates of Adverse Events Following Injections (AEFIs) for the human papillomavirus recombinant vaccine (qHPV) Gardasil were not greater than background rates. They also acknowledge limitations in the re- porting system that could compromise this conclusion. On record as of 1/31/2010 were 15,829 AEFI reports including 49 deaths.
The Science, Ethics and Politics of Vaccine Mandates
Posted in: Vaccines, - size 343.05 kBUniversity of Pennsylvania Center for Bioethics Tuesday, September 21, 2010 9:00am – 4:00pm Sponsored by: The Children’s Hospital of Philadelphia The University of Pennsylvania Health System The Society for Health Care Epidemiology of America Center for Vaccine Ethics and Policy
Vaccine Compensation Injury- Program Challenged to Settle Claims Quickly and Easily
Posted in: Vaccines, - size 619.5 kBHealth, Education, and Human Services Division B-281968 December 22, 1999 The Honorable James M. Jeffords Chairman, Committee on Health, Education, Labor and Pensions United States Senate Dear Mr. Chairman: Infectious diseases are responsible for nearly half of all deaths worldwide of people under the age of 44. In the United States, vaccinating children against such diseases is considered to be one of the most effective public health initiatives ever undertaken. Since vaccination programs began, the number of people contracting vaccine-preventable diseases in the United States has been reduced by more than 95 percent. In some instances, however, a vaccine can have severe side effects, including death or disabling conditions requiring lifetime medical care. In the 1980s, lawsuits stemming from such incidents threatened to affect the the availability and cost of vaccines as well as the development of new ones.
Clinical Review of Biologics License Application Supplement for Human Papillomavirus Quadrivalent (Types 6, 11, 16, 18) Vaccine, Recombinant (Gardasil®) to extend indication for prevention of vaginal
Posted in: Gardasil, - size 2.52 MB3. Executive Summary Merck submitted a Biologics License Application (BLA) Supplement for Gardasil®, a quadrivalent HPV 6/11/16/18 L1 VLP vaccine adjuvanted with aluminum hydroxide, on April 2, 2007 to support additional indications to prevent vulvar and vaginal cancer related to HPV 16 and 18. The supplement BLA should be approved, granting the additional indications to be included in product labeling as well as updated safety and efficacy data to be included in product labeling.
New-Age Vaccine Adjuvants - Friend or Foe?
Posted in: Vaccines, - size 263.39 kBBioPharm International A major unsolved challenge in adjuvant development is how to achieve a potent adjuvant effect while avoiding reactogenicity or toxicity Aug 2, 2007 By: Nikolai Petrovsky, Susanne Heinzel, Yoshikazu Honda, A. Bruce Lyons BioPharm International ABSTRACT Older vaccines made from live or killed whole organisms were effective, but suffered from high reactogenicity. As vaccine manufacturers developed safer, less reactogenic subunit vaccines, they found that with lower reactogenicity came reduced vaccine effectiveness. Somewhat ironically, the solution proposed to boost immunogenicity in modern vaccines is to add back immune-activating substances such as toll-like receptor agonists—the very same contaminants removed from old-style vaccines.
The HPV Vaccine: Science, Ethics and Regulation
Posted in: Human Papillomavirus Vaccine, - size 300.63 kBEconomic & Political Weekly November 27, 2010 Sarojini N B, Sandhya Srinivasan, Madhavi Y, Srinivasan S, Anjali Shenoi Sama- Resource Group for Women & Health A recent civil society-led investigation has highlighted serious ethical violations in a trial of the Human Papilloma Virus vaccine on girls in Khammam district in Andhra Pradesh. The findings are presented along with a review of clinical trials of the hpv vaccine in India and an analysis of the Drugs and Cosmetics Act and Rules. Together they illustrate how the promotional practices of drug companies, pressure from powerful international organisations, and the co-option of, and uncritical endorsement by, India’s medical associations are influencing the country’s public health priorities.
IRISH MEDICINES BOARD UPDATE ON NATIONAL MONITORING EXPERIENCE WITH GARDASIL
Posted in: Gardasil, - size 35.43 kBIrish Medicines Board 9th December 2010 The HSE human papillomavirus (HPV) Schools Immunisation Programme commenced in May 2010 and it is estimated that approximately 60,000 doses of Gardasil have been administered up to the end of November 2010 as part of the programme. At this stage in this year’s School Programme, the majority of girls vaccinated have now received the second dose of the three dose vaccination schedule.
Gardasil Pediatric Utilization and Safety Review for the Pediatric Advisory Committee Meeting — December 7, 2010
Posted in: Gardasil, - size 406.86 kBDepartment of Health and Human Services Food and Drug Administration Center for Biologics Evaluation and Research
The adverse effects of vaccination - critical days
Posted in: Vaccines, - size 98.72 kBby Désirée L. Röver © 2009 The agencies and institutes promoting vaccinations usually are monitoring far too briefly the results of the poisons they have been administering. Additionally they are keeping the mortalityrates unrealistically low: by minimising the vaccination/adverse effect interval, and also by categorically denying the causal link between vaccinations and immune suppression. Next to the causative factor of the disease(s) that one wishes to avoid (...!) vaccines contain a whole range of highly noxious substances: formaldehyde, anti-freeze, mercury and/or aluminium compounds, and unknown quantities of foreign proteins of animal and human origin, as well as human and animal DNA and RNA. Injected straight into the human organism these substances create unprecedented havoc: autoimmune disorders, diabetes, brain damage, cancer.
Gardasil Post-Approval Adverse Event Review
Posted in: Gardasil, - size 186.29 kBDecember 7, 2010 Pediatric Advisory Committee Meeting Michael Nguyen, MD FDA Center for Biologics Evaluation and Research Office of Biostatistics and Epidemiology New Context for Vaccine Safety Surveillance
Vaccines: Get the Full Story - Doctors, Nurses and Scientists on Protecting Your Child and Yourself
Posted in: Vaccines, - size 267.93 kBNatural News A VaccinationCouncil.org Special Report, released by NaturalNews February 2, 2011 "This report is an absolute must-read for parents everywhere. It contains the facts about vaccines, children and immune health that the vaccine manufacturers and government health authorities don't want circulated. Whether or not you choose to vaccinate yourself or your children, you owe it to yourself to hear both side of the story before making a decision, and this report tells you the side of the story your doctor was never taught in medical school." Mike Adams
GARDASIL VACCINATION: EVALUATING THE RISKS VERSUS BENEFITS
Posted in: Gardasil, - size 362.75 kBLucija Tomljenovic, PhD, Neural Dynamics Research Group, Dept. of Ophthalmology, University of British Columbia, 828 W. 10th Ave, Vancouver, BC January 2011 All drugs are associated with some risks of adverse reactions and vaccines are no exception. In weighing risks versus benefits, one has to keep in mind that vaccines represent a special category of drugs since they are generally given to healthy individuals. If there are uncertain benefits from a vaccine, only a small level of risk of harmful effects may be acceptable. If the benefits are certain, then a greater risk of side effects may be tolerated. Here I review the current evidence which indicates that the former case, applies to Gardasil, the quadrivalent human papillomavirus (qHPV) vaccine: 1) The efficacy of Gardasil in preventing cervical cancer has not been demonstrated and the marketing campaign has been misleading. The efficacy of Gardasil remains unsubstantiated since the vaccine hasn’t been adequately tested on the primary age group to which it is currently given.
Hormonal status in protracted critical illness and in-hospital mortality
Posted in: Hormones, - size Critical Care Published: 3 February 2011 Introduction The aim of this study was to determine the relationship between hormonal status and mortality in patients with protracted critical illness. Results We studied 102 patients: 65 men and 37 women (29 of the women were postmenopausal). Twenty-four patients (24%) died in the hospital. The IGF-1 levels were higher and the cortisol levels were lower in survivors. Mean blood glucose was lower in women who survived, and DHEA and DHEAS were higher in men who survived. Conclusions These results suggest that, on the basis of sex, some endocrine or metabolic markers measured in the postacute phase of critical illness might have a prognostic value.
02.11 Letter to Members of the Scottish Parliament
Posted in: Gardasil, - size 51.84 kBWritten by Freda Birrell in response to an article that appeared in the London papers on 2.14.11 calling for Doctors to Give Teenage Girls STD Vaccine. Document out lines risks of Gardasil vs. Cervarix.
Estradiol is associated with mortality in critically ill trauma and surgical patients.
Posted in: , - size PubMed.gov Crit Care Med. 2008 Jan;36(1):62-8. May AK, Dossett LA, Norris PR, Hansen EN, Dorsett RC, Popovsky KA, Sawyer RG. Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, TN, USA. [email protected] Abstract OBJECTIVE: Sexual dimorphism (variation in outcome related to sex) after trauma-hemorrhage and sepsis is well documented in animals, with the pro-estrus state being proinflammatory and associated with a survival advantage. Although some observational studies confirm this pattern in humans, others demonstrate no difference in mortality. Estrogens are important modulators of the inflammatory response and insulin resistance in humans and have been linked to increased mortality during sepsis. Our objective was to determine whether sex hormone levels were associated with outcomes in critically ill surgical patients. MAIN RESULTS: Estradiol was significantly higher in nonsurvivors (p < .001). Analysis by quartiles of estradiol demonstrated greater than a three-fold increase in the mortality rate for the highest vs. the lowest estradiol quartiles (29% vs. 8%, p < .001). Estradiol was also higher in nonsurvivors. An estradiol level of 100 pg/mL was associated with an odds ratio for death of 4.60 (95% confidence interval, 1.56-13.0) compared with a reference estradiol level of 45 pg/mL. CONCLUSIONS: We conclude that serum estradiol correlates with mortality in critically ill and injured surgical patients and discuss potential mechanisms for this observation.
Theoretical aspects of autism: Causes—A review
Posted in: Neurology, Journal of Immunotoxicology, 2011; 8(1): 68–79- size 678.68 kBHelen V. Ratajczak Abstract Autism, a member of the pervasive developmental disorders (PDDs), has been increasing dramatically since its description by Leo Kanner in 1943. First estimated to occur in 4 to 5 per 10,000 children, the incidence of autism is now 1 per 110 in the United States, and 1 per 64 in the United Kingdom, with similar incidences throughout the world. Searching information from 1943 to the present in PubMed and Ovid Medline databases, this review summarizes results that correlate the timing of changes in incidence with environmental changes. Autism could result from more than one cause, with different manifestations in different individuals that share common symptoms. Documented causes of autism include genetic mutations and/or deletions, viral infections, and encephalitis following vaccination. Therefore, autism is the result of genetic defects and/or inflammation of the brain. The inflammation could be caused by a defective placenta, immature blood-brain barrier, the immune response of the mother to infection while pregnant, a premature birth, encephalitis in the child after birth, or a toxic environment.
The Menstrual Cycle: A Feminist Lifespan Perspective
Posted in: Menstrual Cycle, - size 176.07 kBPrepared by the Society for Menstrual Cycle Research | www.menstruationresearch.org I. Introduction A. Why Menstruation Matters The Menstrual Cycle is one of the most important biological differences between females and males, one that has been used – in many contexts — to justify discrimination against women and girls. Thus, the more clearly we understand the biological and social significance of the menstrual cycle for both women and men, the better we understand the fundamental arrangements of human society. Challenging the shame and secrecy surrounding the menstrual cycle, encourages embodied consciousness, or a more meaningful and complex appreciation of bodies across the lifespan. Interdisciplinary menstrual cycle research, especially studies that explore the psychosocial dimensions of menstruation in diverse cultural settings, is an emerging subfield.
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